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Tempo is a nitric oxide radical and a selective scavenger of reactive oxygen species (ROS) in mitochondria. It also functions as an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects, can induce DNA strand breaks, and exhibits cytotoxic and mutagenic properties in mouse lymphoma cells.
Selective scavenger of reactive oxygen species (ROS)
Organocatalyst for superoxide disproportionation
Oxidizes primary alcohols to aldehydes
Exhibits mutagenic and antioxidant effects
Induces DNA strand breaks
Cytotoxic and mutagenic in mouse lymphoma cells
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Mutant p53 modulator-1 is a small-molecule research reagent reported to modulate mutant p53 and to reduce progression of cancers harboring p53 mutations. It is supplied as a powder for laboratory research and includes stability instructions for storage and handling.
High purity: 99.9% suitable for analytical and biological studies.
Defined chemical formula: C27H32F4N8O2 for unambiguous identification.
Documented stability: powder stable at -20°C for long-term storage.
Reported activity against mutant p53 to support targeted cancer research.
Intended for research use only, not for human or clinical use.
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GLP-1R modulator C16 is a small-molecule allosteric modulator that enhances GLP-1 binding to the GLP-1 receptor via a transmembrane site (CAS 875005-43-9). It is characterized in vitro with an EC50 of 8.43 ± 3.82 μM, a molecular weight of 408.89 g·mol⁻1, and high chemical purity suitable for research applications.
Allosteric modulator of GLP-1 receptor activity.
Characterized potency (EC50 8.43 ± 3.82 μM) for in vitro studies.
High chemical purity (99.6%) for reproducible results.
Compact quantities suitable for early-stage pharmacology.
Useful for studying GLP-1R pharmacology and GPCR signaling.
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TUG-770 (CAS 1402601-82-4) is a potent agonist of the free fatty acid receptor 1 (FFA1/GPR40) a G protein-coupled receptor implicated in the enhancement of glucose-stimulated insulin secretion by pancreatic -cells TUG-770 demonstrates high affinity for FFA1 with an EC50 of 6 nM and over 150-fold selectivity compared to FFA4 as well as high selectivity over other receptors and transporters In INS-1E rat -cell lines TUG-770 promotes insulin secretion in the presence of elevated glucose Pharmacokinetic studies in mice indicate favorable oral absorption and bioavailability with dose-dependent reductions in blood glucose during glucose tolerance tests TUG-770 is a valuable tool for investigating FFA1-mediated pathways and glucose homeostasis in metabolic research
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Diallyl disulfide is an organosulfur compound derived from garlic oil. It is reported as an orally active human squalene monooxygenase inhibitor (IC50 ≈400 μM) and has been investigated for anti-inflammatory, antioxidant, antidepressant, and antitumor activities.
Organosulfur compound with molecular formula C6H10S2 and molecular weight 146.27 g/mol.
Orally active squalene monooxygenase inhibitor (IC50 ≈400 μM).
Reported biological activities include anti-inflammatory, antioxidant, antidepressant, and antitumor effects.
High purity analytical grade available (≈98.4% per data sheet).
Storage: store at 4°C under nitrogen; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
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